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KMID : 0981820090290030185
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Korean Journal of Laboratory Medicine
2009 Volume.29 No. 3 p.185 ~ p.193
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Incidence and Causes of Hyperosinophilia in the Patients of a University Hospital
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Kim Da-Woon
Shin Myung-Geun
Yun Hyeong-Kee
Kim Soo-Hyun
Shin Jong-Hee
Suh Soon-Pal
Ryang Dong-Wook
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Abstract
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Background : Eosinophilia may be associated with various primary and reactive conditions. The incidence and the causes of eosinophilia might have been changed according to the changes in the incidence of diseases such as cancer, chronic degenerative diseases, etc. We have conducted a retrospective study to investigate the incidence and causes of eosinophilia.
Methods : Eosinophilia and hypereosinophilia were defined when absolute eosinophil count was greater than 500/μL and 1,500/μL, respectively. Patient’s clinical records were reviewed to find out the underlying clinical conditions responsible for causes of hypereosinophilia. Conventional chromosomal analysis, reverse transcriptase PCR and FISH for gene rearrangement were performed to check the presence of clonal eosinophilia.
Results : Out of 41,137 patients who had a hematology profile performed, 5,019 (12.2%) and 373 patients (0.9%) were found to have eosinophilia and hypereosinophilia, respectively. Among patients with hypereosinophilia, 227 patients (60.9%) had identifiable and/or possible causes. The major causes of hypereosinophilia were malignancy (35.2%), allergy and skin diseases (18.1%), infectious diseases (15.4%), hepatobiliary diseases (7.5%), bone marrow clonal diseases (6.6%) and parasite infections (6.6%). We also found a rare case of FIP1L1-PDGFRαpositive chronic eosinophilic leukemia combined with light chain multiple myeloma.
Conclusion : We found a difference in the distribution of causes of hypereosinophilia in comparison with previous Korean studies, and the most common cause of hypereosinophilia in the current study was malignancy. A rare case of clonal eosinophilia (chronic eosinophilic leukemia) associated with multiple myeloma was confirmed using molecular studies.
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KEYWORD
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Incidence, Cause, Eosinophilia, Hypereosinophilia
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